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Dr. PAUL MARINEC
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Address 1
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Address 2
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Title
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Dr.
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First Name
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PAUL
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Last Name
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MARINEC
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University/Institution
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University of California, San Francisco
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Phone #
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4155144506
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Email ID
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paul.marinec@ucsf.edu
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City
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San Francisco
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Country
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United States
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State
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California
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Zipcode
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94158
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Department
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Pharmaceutical Chemistry
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Company Name
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Area of Research
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Antibody Engineering
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Area of Expertise
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Protein Engineering, Chemical Biology, Combinatorial Chemistry, Molecular Biology
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Brief Description of Research Interest :
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Engineering stability into antibody scaffolds for use as intracellular therapeutics.
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Representative Publications :
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Congdon, E.E., Yu, W. H., Figueroa, Y.H., Marinec, P. S., Gestwicki, J.E., Dickey, C. A., and Duff, K. E.
Methylthioninium Chloride (MethyleneBlue) Induces Autophagy and Attenuates Tauopathy in vitro and in vivo.
Autophagy, 2012,8:4.
O’Leary, J. C., Li, Q., Marinec, P. S., Blair, L. J., Congdon, E.E., Johnson, A. G., Jinwal, U. K., Koren, J., Jones, J. R.,
Kraft, C., Peters, M., Abisambra, J. F.,Duff, K. E., Weeber, E. J., Gestwicki, J. E., and Dickey, C. A., Phenothiazine-
Mediated Rescue of Cognition in TauTransgenic Mice Requires Neuroprotection and Reduced Soluble Tau Burden.
MolecularNeurodegeneration, 2010, 5: 45-55.
Marinec,P. S., Evans,C. G., Gibbons, G. S., Tarnowski, M. A., Overbeek, D. L., and Gestwicki, J. E.,
Microwave-Assisted Organic Synthesis ofOrthogonally Reactive FK506-Derivatives via Olefin Cross Metathesis.
BioorganicMedicinal Chemistry, 2009, 17: 5763-5768.
Marinec,P. S.,Chen, L., Barr, K. J., Mutz, M. W., Crabtree, G. R., and Gestwicki, J. E., FK506-Binding Protein
(FKBP) Partitions a Modified HIVProtease Inhibitor Into Blood Cells and Prolongs its Lifetime In Vivo.
Proceedings ofthe National Academy of Sciences, 2009, 106: 1336 - 1341.
Marinec,P. S.,Lancia, J. K., and Gestwicki, J. E., Bifunctional Molecules Evade Cytochrome P450
Metabolism by Forming Protective Complexeswith FK506-Binding Protein.
Molecular Biosystems,2008, 4: 571 - 578.
Kim, O. J., Ariano, M. A., Namkung, Y., Marinec, P. S., Kim, E., Han, J.,Sibley, D.R., D2 Dopamine
Receptor Expression and Trafficking isRegulated Through Direct Interactions with ZIP.
Journal ofNeurochemistry, 2008, 106: 83 - 95.
Gestwicki, J. E. and Marinec, P. S.,Chemical Control Over Protein-Protein Interactions: Beyond Inhibitors.
CombinatorialChemistry & High Throughput Screening, 2007, 10: 667 - 675.
Rankin, M. L.,Marinec, P. S., Cabrera, D. M., andSibley, D. R., The D1 Dopamine Receptoris Constitutively
Phosphorylatedby G Protein-Coupled Receptor Kinase 4: Evidencefor a Novel Mechanism of Regulation.
MolecularPharmacology, 2006, 69: 759 - 769.
Kim, O. J.,Gardner, B. R., Williams, D. B., Marinec,P. S., Cabrera, D. M., Peters, J. D., Kim, K. M., and Sibley, D. R.,
The Role of Phosphorylation in D1 Dopamine Receptor Desensitization: Evidence for a Novel Mechanism of Arrestin Association.
Journalof Biological Chemistry, 2004, 279: 7999 - 8010.
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