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Dr. SHANKAR SWAMINATHAN
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Address 1
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Address 2
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Title
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Dr.
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First Name
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SHANKAR
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Last Name
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SWAMINATHAN
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University/Institution
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University of Tennessee Health Science Center
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Phone #
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8577567292
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Email ID
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sswamin4@uthsc.edu
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City
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Memphis
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Country
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United States
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State
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Tennessee
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Zipcode
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38105
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Department
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Ophthalmology
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Company Name
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Area of Research
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Genetics, drug delivery science, personalized medicine, glaucoma, age related macular degeneration
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Area of Expertise
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Pharmacokinetics, drug delivery, Systems biology, vision research
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Brief Description of Research Interest :
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- Brief Biography:
- Dr. Swaminathan is a pharmaceutical scientist and polymer chemist turned into an eye/vision researcher. Dr. Swaminathan received his Ph.D. in Pharmaceutics from the Institute of Chemical Technology, Mumbai, India. He was also a research assistant at the University of Turin, Italy during his Ph.D. He went on to gain research experience in the industry after his Ph.D. specializing in long acting polymeric medical devices for contraception where he was instrumental in getting the product to the scale up stage. He then decided to fortify his repertoire further by gaining postdoctoral research experience in the US in eye/vision research.
- Currently, a postdoctoral researcher at the University of Tennessee Health Science Center. His research revolves around studying genetic modifiers of glaucoma with a special emphasis on intraocular pressure and developing personalized nanomedicine. Research involves gene mining using bioinformatics tools and systems genetics. He is also a part of the team developing novel nano-therapies for dry age related macular degeneration. He has been a part of a stellar team studying genetic modifiers of iris transillumination defects in the eye.
- Pioneered the work on Nanosponge synthesis and applications in drug delivery.
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- Pursuing active research in drug delivery technology, personalized medicine, nanotechnology, ocular drug delivery, ocular pharmacokinetics, systems biology, bioinformatics, solublization of drug actives, medical devices, etc.
- General research interests revolve around providing value added medicine to alleviate diseases by applying polymeric nanoparticle technology, controlled drug delivery, solubilization, cyclodextrin based drug delivery systems, ocular pharmacokinetics and biodistribution. Solid dispersion, drug/particle/pellet coating, pellets into tablet technology, Silicone based controlled release medical devices for contraception, Intrauterine medical devices, anticancer drug therapy optimization by solubilization and bioavailability enhancement, stabilization of macromolecules/proteins by use of nanosponge technology, physicochemical stabilization of molecules.
- He is also interested in the commercial aspects of research dealing with bench to market transition of a product, and product licensing. He has keen interest in the FDA regulations and IP related issues pertaining to product filings.
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Representative Publications :
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- Shankar Swaminathan, Monica M. Jablonski, Hong Lu, Robert W. Williams and Lu Lu, Genetic Modulation of the Iris Transillumination Defect: A Systems Genetics Analysis using the Expanded Family of BXD Glaucoma Strains, Pigment Cell and Melanoma Research (2013): doi: 10.1111/pcmr.12106
- Shankar Swaminathan, Pradeep R. Vavia, Francesco Trotta, Roberta Cavalli, Cyclodextrin based Nanosponges encapsulating dexamethasone for ocular delivery: Physicochemical characterization and corneal permeability assessment, Journal of Biomedical Nanotechnology, Vol. 9, No. 6, 998-1007 (2013). doi:10.1166/jbn.2013.1594.
- David Lembo, Shankar Swaminathan, Manuela Donalisio, Andrea Civra, Linda Pastero, Dino Aquilano, Pradeep Vavia, Francesco Trotta, Roberta Cavalli, Acyclovir loaded Nanosponges: Characterization, Cellular internalization, and Enhanced antiviral activity, International Journal of Pharmaceutics (2013), 443(1-2): 262-72. doi: 10.1016/j.ijpharm.2012.12.031 (PMID: 23279938).
- Shankar Swaminathan, Sangwai Mayur, Wawdhane S. and Vavia P.R., Soluble itraconazole in tablet form using disordered drug delivery approach: Scale up and biostudies, AAPSPharmSciTech (2013), 14(1): 360-74. doi: 10.1208/s12249-012-9918-9 (PMID: 23334999).
- Shankar Swaminathan and Monica Jablonski, Non biological membranes as drug delivery systems; Journal of Membrane Science and Technology (2012), 2 (3) http://dx.doi.org/10.4172/2155-9589.1000e108.
- Shankar Swaminathan, Sharad Darandale, Vavia,P.R., Nanosponge Aided Drug Delivery: A closer look, invited review, Pharmaceutical Formulation and Quality (2012), Oct-Nov.
- Shankar Swaminathan, Vavia, P.R, Trotta, F., Cavalli, R, Tumbiolo, S. Bertinetti, L. Coluccia, S., Structural evidence of differential forms of Nanosponges of beta-cyclodextrin and its effect on solubilization of a model drug, Journal of Inclusion Phenomenon and Macrocyclic Chemistry (2012), doi: 10.1007/s10847-012-0192-y.
- Shankar Swaminathan, Pastero, L., Serpe, L., Trotta, F., Vavia, P.R, Aquilano, D., Trotta, M., Zara, G.P., Cavalli, R, Nanosponge Based Camptothecin Formulations: Physico-Chemical Characterization, Stability and Cytotoxicity, European Journal of Pharmaceutics and Biopharmaceutics (2010), 74 (2) 193-201 (PMID: 19900544).
- Shankar Swaminathan, Vavia, P.R, Cavalli, R., Trotta, F., Ferruti, P., Ranucci, E., Gerges, I., Manfredi, A., In vitro release modulation and conformational stabilization of a model protein using swellable polyamidoamine nanosponges of β Cyclodextrin, Journal of Inclusion Phenomenon and Macrocyclic Chemistry (2010), Volume 68, Numbers 1-2, 183-191.
- Shankar Swaminathan, Vavia, P.R., Trotta, F., Torne, S.; Formulation of Itraconazole Nanosponges. Journal of Inclusion Phenomenon and Macrocyclic Chemistry (2007), Volume 57 (1-4), P 89-94.
- In Preparation:
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- Shankar Swaminathan, Hong Lu, Robert W. Williams, Lu Lu, and Monica M. Jablonski, Genetic modulation of IOP in Glaucoma, Human Molecular Genetics (manuscript in preparation).
- Shankar Swaminathan, Huiling Li, Mallika Palamoor, Bernd Meibohm, and Monica M. Jablonski, Assessment of safety, in ocular pharmacokinetics and bio-distribution of a novel endogenous glycan for retinal diseases, Clinical Pharmacology and Therapeutics (manuscript in preparation).
- Shankar Swaminathan, Bernd Meibohm, and Monica M. Jablonski, Stability assessment of a novel endogenous glycan for atrophic age related macular degeneration in plasma and excised vitreous AAPS Pharm.Sci.Tech. (manuscript in preparation).
- Shankar Swaminathan and Monica Jablonski, Nanoengineering strategies for front of the eye diseases- Journal of Nanomedicine and Nanotechnology (2013). Invited review in preparation.
- Cavalli, R., Shankar Swaminathan, A., Vavia, P.R, Bisazzaa, A. Civra M. Donalisio, D. Savoia, E. Ghibaudi, L. Pastero , D. Aquilano, A. Manfredi, F. Fenili, E. Ranucci, D. Lembo P, pH-sensitive β-cyclodextrin-based nanogels for the encapsulation and controlled release of proteins. , Journal of Inclusion Phenomenon and Macrocyclic Chemistry, Under review (2013).
- Shankar Swaminathan, Pradeep R. Vavia, Francesco Trotta, Roberta Cavalli, Functionalization of beta cyclodextrin based nanosponges, interaction studies and in vitro release modulation of model molecules by layer engineering Journal of microencapsulation (manuscript in preparation).
- Shankar Swaminathan, Pradeep R. Vavia, Francesco Trotta, Roberta Cavalli, Loredana Serpe, Gian Paolo Zara., Functionalized Beta Cyclodextrin Nanosponge Based Stable Formulation of Camptothecin and In vitro Cytotoxicity Evaluation, European Journal of Pharmaceutics and Biopharmaceutics (manuscript in preparation).
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