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  Dr. MITCHELL MENEZES  
 
Address 1 :
Address 2 :
Title : Dr.
First Name : MITCHELL
Last Name : MENEZES
University/Institution : Virginia Commonwealth University
Phone # : 8046283337
Email ID : memenezes@vcu.edu
City : Richmond
Country : United States
State : Virginia
Zipcode : 23298
Department : Human and Molecular Genetics
Company Name :
Area of Research
Basic Cancer Research
Area of Expertise
Cancer Research, Molecular Biology
Brief Description of Research Interest :
My research interests include determining the molecular mechanisms that are deregulated during cancer initiation, progression and metastasis and using viruses and small molecule inhibitors to specifically target cancer cells.
Representative Publications :

1.   MitraA., Menezes M.E., Shevde L.A., Samant R.S. DNAJB6 induces degradation of beta-cateninand causes partial reversal of mesenchymal phenotype. Journal of Biological Chemistry, 2010 Aug 6; 285(32): 24686-94. PMID: 20522561.

2.  Menezes M.E., Devine D.J., Shevde L.A., Samant R.S. Dickkopf1: A tumor suppressor or metastasispromoter. International Journal of Cancer, 2012 Apr 1;130(7):1477-83. PMID: 21953410.

3.  Mitra A., MenezesM.E., Pannell L.K., Mulekar M., Honkanen R.E., Shevde L.A., Samant R.S.DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulateβ-catenin transcription target, osteopontin Oncogene, 2012 Oct11;31(41):4472-83. PMID: 22266849.

4.  Menezes M.E., Mitra A. ShevdeL.A., Samant R.S. DNAJB6 governs anovel regulatory loop determining Wnt/b-catenin signaling activity. Biochemical Journal,2012 Jun 15;444(3):573-80. PMID: 22455953.

5.  Andrews J.F., Sycora L.J., Letostak T.B, Menezes M.E., Mitra A., BarikS., Shevde L.A., Samant R.S. Cellular stress stimulates nuclear localizationsignal (NLS) independent nuclear transport of MRJ. Experimental Cell Research. 2012 Jun 10; 318(10):1086-93. PMID:22504047.

6.  Hedvat M., Emdad L., Das S.K., Kim K., DasguptaS., Thomas S., Hu B., Zhu S., Dash R., Quinn B.A., Oyesanya R.A., KegelmanT.P., Sokhi U.K., Sarkar S., Erdogan E., MenezesM.E., Bhoopathi P., Wang X.Y., Pomper M.G., Wei J., Wu B., StebbinsJ.L., Diaz P.W., Reed J.C., Pellecchia M., Sarkar D., Fisher P.B. Selectedapproaches for rational drug design and high throughput screening to identifyanti-cancer molecules. Anti-cancer Agentsin Medicinal Chemistry. 2012 Aug 23 PMID: 22931411.

7.  Bhutia S.K., Das S.K., Azab B., Menezes M.E., Dent P., WangX.Y., Sarkar D., Fisher P.B. Targeting breast cancer-initaiting/stem cells withmelanoma differentiation-associated gene-7/interleulin-24. International Journal of Cancer. 2013 May 30 PMID: 23720015.

8.  BhatiaS.*, Menezes M.E.*, Das S.K.,Emdad L., Dasgupta S., Wang X.Y., Sarkar D., Fisher P.B. Innovative approachesfor enhancing cancer gene therapy. Discovery Medicine. 2013 May 15(84):309-317 PMID 23725604 (* Co-first authors)

9.  DasguptaS, Menezes M.E., Das SK,Emdad L., Janjic A., Bhatia S., Mukhopadhyay N, Shao C., Sarkar D., Fisher P.B.Novel role of MDA-9/syntenin in regulating urothelial cell proliferation bymodulating EGFR signaling. Clinical Cancer Research. 2013 Jul 19 PMID:23873690. Impact factor 7.837

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