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Dr. ADAM WALKER
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Address 1
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Address 2
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Title
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Dr.
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First Name
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ADAM
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Last Name
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WALKER
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University/Institution
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University of Pennsylvania
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Email ID
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adwa@upenn.edu
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City
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Philadelphia
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Country
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United States
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State
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Pennsylvania
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Zipcode
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19104
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Department
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Department of Pathology and Laboratory Medicine
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Company Name
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Area of Research
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Neurodegenerative disease
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Area of Expertise
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Biochemistry, cell biology, mouse models of neurological diseases
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Brief Description of Research Interest :
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The DNA/RNA-binding protein TDP-43 is the key pathological protein in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), however how dysfunction of TDP-43 leads to devastating neurodegeneration remains unknown. Using cell and mouse model systems and studies of human autopsy brain and spinal cord tissue, my research aims to better understand the pathogenic pathways, including cellular stress responses, that are involved in TDP-43-linked disease. I am also developing new TDP-43 models which recapitulate key features of human pathology in order to dissect the timeline of molecular changes in disease and to provide new methods for pre-clinical studies of ALS and FTD.
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Representative Publications :
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WalkerAK,LaPash Daniels CM, Goldman JE, Trojanowski JQ, Lee VM-Y, Messing A, (2014)‘Astrocytic TDP-43 pathology in Alexander disease’, The Journal ofNeuroscience, 34(19): 6448-6458.
KwongLK, Irwin DJ, Walker AK, Xu Y, Riddle DM,Trojanowski JQ, Lee VM-Y, (2014) ‘Novel monoclonal antibodies to normaland pathologically altered human TDP-43 proteins’, Acta NeuropathologicaCommunications, 2: 33.
Atkin JD, Farg MA, Soo KY, Walker AK, Halloran M, Turner BJ, Nagley P, Horne MK, (2013), ‘Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis’, Journal of Neurochemistry, 129(1): 190-204.
Walker AK, Soo KY, Sundaramoorthy V, Parakh S, Ma Y, Farg MA, Wallace RH, Crouch PJ, Turner BJ, Horne MK, Atkin JD, (2013), ‘ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation’, PLoS One, 8(11): e81170.
Sundaramoorthy V, Walker AK, Yerbury J, Soo KY, Farg MA, Hoang V, Zeineddine R, Spencer D, Atkin JD, (2013), ‘Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells’, Cellular and Molecular Life Sciences, 70(21):4181-4195.
Walker AK, Soo KY, Levina V, Talbo G, Atkin JD, (2013), ‘N-linked glycosylation modulates dimerisation of protein disulfide isomerase family A member 2 (PDIA2)’, FEBS Journal, 280(1): 233-243.
Farg MA, Soo KY, Walker AK, Pham H, Orian J, Horne MK, Warraich ST, Williams KL, Blair IP, Atkin JD, (2012), ‘Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase’, Neurobiology of Aging, 33: 2855-2868.
Walker AK, Farg MA, Bye CR, McLean CA, Horne MK, Atkin JD, (2010), ‘Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis’, Brain, 133(1): 105-16.
Atkin JD, Farg MA, Walker AK, McLean C, Tomas D, Horne MK, (2008), ‘Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis’, Neurobiology of Disease, 30(3):400-7.
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Resume
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