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Dr. ARUNA PODURI
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Address 1
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Address 2
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Title
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Dr.
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First Name
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ARUNA
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Last Name
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PODURI
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University/Institution
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Stanford University
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Email ID
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arunapoduri@gmail.com
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City
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Stanford
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Country
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United States
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State
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California
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Zipcode
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94305
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Department
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Biology
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Company Name
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Area of Research
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Cardiovascular Biology
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Area of Expertise
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Cellular and Molecular Mechanisms of Vascular Diseases
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Brief Description of Research Interest :
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My research work is focused in characterizing the cellular and molecular mechanisms that initiatesand promotes vascular remodeling of the blood vessels. My researchexperience has been mainly in vascular biology with focus on human clinical samples and mouse models. In my graduation, I investigated the role of cholesterol and statin metabolism genes in coronary heart disease patients. Also studied the role of inflammatory and contractile proteins in these patients. During my post doc,I have examined the effects of vascular cell types on Angiotensin II-induced atherosclerosis and aortic aneurysms in mice models. Currently, I am working to determine the molecular and cellular mechanisms of coronary artery stem formation in a mouse embryo.
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Representative Publications :
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- Poduri A, Mukherjee D, Sud K, Kohli HS, Sakhuja V, Khullar M. MTHFR A1298C polymorphism is associated with cardiovascular risk in end stage renal disease in North Indians. Mol Cell Biochem; 2008; 308: 43-50. Epub 2007 Sep 25; PMID: 17899317.
- Poduri A, Kaur J, Thakur JS, Kumari S, Khullar M. Effect of ACE inhibitors and Beta blockers on Homocysteine levels in Essential Hypertension. J Hum Hypertens. 2008; 22 (4): 289-94. Epub 2008 Jan 17; PMID: 18200034
- Poduri A, Kumari S, Jain S, Khullar M. A case-control study of the association between the MTHFR gene and essential hypertension in Asian Indians. J Hum Hypertens. 2009; 23(2):140-2; PMID: 18754019
- Poduri A, Bahl A, Sharma YP, Talwar KK, and Khullar M. A Combination of Pro-atherogenic Single Nucleotide Polymorphisms is associated with increased risk of Coronary Artery Disease and Myocardial Infarction in Asian Indians. DNA Cell Biol. 2009 Sep;28(9):451-60; PMID: 19558216
- Daugherty A, Poduri A, Chen X, Lu H, Cassis LA. Genetic Variants of the Renin Angiotensin System: Effects on Atherosclerosis in Humans and Experimental Models. Curr Athero Rep. 2010 May; 12(3):167-73. PMID: 20425255
- Poduri A , Khullar M, Bahl A, Sehrawat BS, Sharma YP, Talwar KK. Common variants of HMGCR, CETP, APOAI, ABCB1, CYP3A4, CYP7A1 genes as predictors of lipid lowering response to Atorvastatin therapy. DNA Cell Biol. 2010 Jun 26 PMID: 20578904
- Rateri DL, Moorleghen JJ, Balakrishnan A, Owens AP, Howatt DA, Subramanian V, Poduri A, Charnigo R, Cassis LA, Daugherty A. Endothelial Cell-specific Deficiency of AngII Type1a Receptor Attenuates Ang II-Induced Ascending Aortic Aneurysms in LDL Receptor -/- mice. Circ Res. 2011 Mar 4; 108(5):574-81; PMID: 21252156
- Uchida HA*, Poduri A*, Subramanian V, Cassis LA, Daugherty A. uPA Deficiency in Bone-Marrow- derived cells Augments Rupture of Angiotensin II-induced Abdominal Aortic Aneurysms. *Shared First Authorship Arterioscler Thromb Vasc Biol. 2011 Aug 25; PMID: 21868698
- Poduri A, Khullar M, Bahl A, Talwar KK. Proteomic analysis of circulating human monocytes in coronary artery disease. Mol Cell Biochem. 2011; PMID: 2193840
- Poduri A, Rateri DL, Saha SK, Saha S, Daugherty A. Citrullus lanatus ‘sentinel’ extract reduces atherosclerosis in LDL receptor deficient mice. J Nutr Biochem 2012 Aug 16. PMID: 22902326
- Poduri A, Howatt DA, Balakrishnan A, Cassis LA and Daugherty A. Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms. Plos ONE 2012 Oct 31; 7(10):e48462 PMID: 23119030
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Resume
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