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Dr. QUAISAR ALI
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Address 1
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Address 2
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Title
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Dr.
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First Name
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QUAISAR
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Last Name
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ALI
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University/Institution
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University of Oklahoma Health Sciences Center
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Phone #
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3343323367
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Email ID
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quaisar-ali@ouhsc.edu
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City
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Oklahoma City
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Country
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United States
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State
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Oklahoma
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Zipcode
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73103
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Department
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Physiology
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Company Name
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Area of Research
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Hypertension
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Area of Expertise
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Renal Physiology, Obesity, Hypertension, Pulmonary Arterial Hypertension, Cardiovascular disorders
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Brief Description of Research Interest :
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Kidney is the major organ which regulates sodium excretion/absorption and thus prevents the progression of hypertension and kidney disease. Distal tubules in the kidney though absorb 5% of the sodium but is the major contributor of sodium homeostasis because it finely tunes the absorption/excretion. Our laboratory has shown that aging people develop hypertension and this occurs by the inability of distal tubules of kidney to regulate sodium. I am trying to investigate if over expression of klotho gene which is called as anti-aging gene (because it delays the process of aging) can prevent hypertension in aging/population. The successful completion of this project will unravel the novel pathways as to how anti-aging gene klotho play a role in blood pressure regulation in aging condition. The life of old/aged people having hypertension will significantly improve if this project is successfully completed
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Representative Publications :
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1. Sourashish Nag, Mohammed Khan, Preethi Samuel, Quaisar Ali, TahirHussain. Chronic angiotensin AT2R activation prevents high-fat diet-inducedadiposity and obesity in female mice. Acceptedin Metabolism (January 2015)
- Quaisar Ali, Yonnie Wu, Sourashish Nag, Tahir Hussain. Quantification of angiotensin peptides in kidney cortex and adipose tissue by LC/MS. Analytical Methods, 2013 6(1): 215-222.
- Quaisar Ali, Yonnie Wu, Tahir Hussain. Chronic treatment with AT2 receptor agonist CGP42112A reduces AT1 receptor function and increases ACE2 activity in obese Zucker rats. Kidney International (2013) 84(5): 931-939.
- Isha Dhande, Quaisar Ali, Tahir Hussain. Proximal tubule Angiotensin AT2 receptors mediate an anti-inflammatory response via interleukin-10: role in renoprotection in obese rats. 2013. Hypertension, 61(6) 1218-1226
5. Quaisar Ali, Tahir Hussain. AT2 receptor: Its role in obesityassociated hypertension. Int J ClinPharm and Toxicol (2012)1:2.
6. Quaisar Ali, Tahir Hussain. AT2 receptor non-peptide agonist C21 promotesnatriuresis in obese Zucker rats. HypertensionResearch (2012) 35(6): 654-660.
- Preethi Samuel, Quaisar Ali, Rifat Sabuhi, Yonnie Wu, Tahir Hussain. High sodium intake reduces the expression of renal ACE2-AT2-MasR axis in obese Zucker rats. AJP Renal Physiology (2012) 303(3): F412-9.
- Rifat Sabuhi,*Quaisar Ali,* Mohammed Ashgar, Najah Hadi, Tahir Hussain. Role of angiotensin II AT2 receptor in inflammation and oxidative stress: Opposing effects in lean and obese Zucker rats. AJP Renal Physiology (2011) 300 (3): F700-706.*Joint 1st Author.
- Quaisar Ali, Rifat Sabuhi, Tahir Hussain. High glucose up-regulates Angiotensin II Subtype 2 Receptors via Interferon Regulatory Factor-1 In proximal tubule epithelial cells. Molecular and Cellular Biochemistry (2010) Nov; 344 (1-2): 65-71.
10. Siddiqui AH, Quaisar Ali, Tahir Hussain. Protective role ofangiotensin II subtype 2 receptor in blood pressure increase in obese Zuckerrats. Hypertension(2009) 53(2):256-261.
11. JantaroS, Quaisar Ali, Samea Lone, QingfangHe. Suppression of the lethality of high light to a quadruple HLI mutant by theinactivation of the regulatory protein PfsR in Synechocystis PCC 6803. J Biological Chemistry. (2006) 281 (41): 30865-74.
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Resume
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