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Dr. ISABEL CALVO
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Address 1
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Address 2
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Title
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Dr.
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First Name
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ISABEL
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Last Name
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CALVO
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University/Institution
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Massachusetts General Hospital-Harvard
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Phone #
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0016172916322
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Email ID
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isabelcalvo83@gmail.com
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City
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Charlestown Boston
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Country
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United States
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State
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Massachusetts
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Zipcode
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02129
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Department
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Cancer Center
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Company Name
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Area of Research
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Epigenetics
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Area of Expertise
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RNA-mediated epigenetic gene silencing and metabolism
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Brief Description of Research Interest :
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In Dr.Motamedi´s lab we focuson understanding how chromatin and non-coding RNAs regulate epigeneticinheritance using the best eukaryotic model system to study this problem, thefission yeast, S. pombe.
Epigeneticsis a molecular memory system by which a cell ensures that the same geneexpression pattern is inherited at division thus establishing stable celllineages throughout development. In cancers, cells lose their ability to retaintheir correct identity and display aberrant gene expression patterns.Epigenetic aberrations occur at all stages of malignancies, from tumorformation to metastasis.
One of mycurrent goals is to harness the powerful genetic, biochemical and cellbiological tools available in the fission yeast to drive novel discoveries inRNA-dependent chromatin biology and to examine the contribution of thesepathways in oncogenesis.
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Representative Publications :
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1. Boronat, S., Domènech, A., Paulo, E., Calvo, I.A., García-Santamarina, S., García, P., Encinar del Dedo, J., Barcons, A., Serrano, E., Carmona, M. and Hidalgo, E. Thiol-based H2O2 signalling in microbial systems. Redox Biol. 2014 Feb 3; 2:395-9. doi: 10.1016/j.redox.2014.01.015. eCollection 2014. Review.
2.- Paulo, E.*, García-Santamarina, S.*, Calvo, I.A.*, Carmona, M., Boronat, S., Domènech, A., Ayté, J. and Hidalgo, E. 2014. A genetic approach to study H2O2 scavenging in fission yeast – distinct roles of peroxiredoxin and catalase. Molecular Microbiology 2014 Apr;92(2):246-57. doi: 10.1111/mmi.12548. Epub 2014 Mar 6.
(*) E.P., S.G. and I.A.C. contributed equally to this work.
3.- Calvo, I.A., Boronat, S., Domènech A., García-Santamarina, S., Ayté, J. and Hidalgo, E. Dissection of a redox relay: the peroxiredoxin Tpx1 and the transcription factor Pap1 are oxidized by H2O2 and reduced by thioredoxin. Cell Reports 2013 Dec 12;5(5):1413-24
4.- Calvo, I.A., Ayté, J. and Hidalgo, E. 2013. Reversible thiol oxidation in the H2O2-dependent activation of the transcription factor Pap1. J. Cell Sci. May 15;126(Pt 10):2279-84.
5. García-Santamarina S, Boronat S, Calvo, I.A., Rodríguez-Gabriel M, Ayté J, Molina H, Hidalgo E. (2012). Is oxidized thioredoxin a major trigger for cysteine oxidation? Clues from a redox proteomics approach. Antioxid Redox Signal. May 1;18(13):1549-56.
6.- Calvo, I.A., García, P., Ayté, J. and Hidalgo, E. (2012) The transcription factors Pap1 and Prr1 collaborate to activate antioxidant, but not drug tolerance, genes in response to H2O2. Nucleic Acids Res 40 Jun 1;40 (11):4816-24.
7.-Gómez-Escoda, B., Ivanova, T., Calvo, I.A., Alves-Rodrigues, I., Hidalgo, E. and Ayte, J. (2011) Yox1 links MBF-dependent transcription to completion of DNA synthesis. EMBO Reports 12:84-89.
8. Calvo, I.A., Gabrielli, N., Iglesias-Baena, I., García-Santamarina, S., Hoe, K.L., Kim, D.U., Sansó, M., Zuin, A., Pérez, P., Ayté, J. and Hidalgo, E. (2009) Genome-wide screen of genes required for caffeine tolerance in fission yeast. PLoS ONE 4(8):e6619.
9. Zuin, A. *, Calvo, I.A. *, Gabrielli, N. *, García-Santamaría, S., Hoe, K.-L., Kim, D.U., Park, H.-O., Hayles, J., Ayté, J. and Hidalgo, E. (2008) Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast. PLoS ONE 3:e2842. (*) The first three authors contributed equally to this work
10. Jara, M., Vivancos, A.P., Calvo, M.I., Moldón, A., Sansó, M and Hidalgo, E. (2007) The peroxirredoxin Tpx1 is essential as a H2O2-scavenger during aerobic growth in fission yeast. Mol. Biol. Cell 18:2288-2295. (under review)
11. Laura A. Laviolette, Julien Mermoud, Isabel A. Calvo, Nicholas Olson, Myriam Boukhali, Dachuan Huang, Bin Tean Teh, Mo Motamedi, Wilhelm Haas, and Othon Iliopoulos. Negative Regulation of EGFR Signaling by the Human Folliculin (FLCN) Tumor Suppressor Protein. Nature Communications. (Under review)
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