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  Dr. XIANG BAI  
 
Address 1 :
Address 2 :
Title : Dr.
First Name : XIANG
Last Name : BAI
University/Institution : Brigham and Women's Hospital Harvard Medical School
Email ID : xbai2@partners.org
City : Boston
Country : United States
State : Massachusetts
Zipcode : 02115
Department : Pathology
Company Name :
Area of Research
Neurodegeneration, Aging, Alzheimer's disease, Parkinson's disease
Area of Expertise
Pharmacology, Neuroscience, Aging
Brief Description of Research Interest :

My dissertation research investigated mechanisms underlying therapeutic effects of rapamycin in a mouse model of Synucleinopathy. My current research is to elucidate mechanisms linking pathologies caused by pathological protein markers of Parkinson’s disease (synuclein) and Alzheimer’s disease(Abeta and tau).

Representative Publications :

1.     Bai X, Wey MCY, Fernandez E, Hart MJ, Gelfond J,Bokov AF, Rani CS and Strong R.  Rapamycin improves motor function, reduces 4-hydroxynonenal-adducted protein in brain and   attenuates synaptic injury in a mouse model of synucleinopathy. Pathobiology of Aging & Age-related Diseases. 5: 10.3402/pba.v5.28743. PMCID: PMC4549373. 2015.

 

2.       Bai X and Strong R. Expression of synaptophysin proteinin different dopaminergic cell lines. Journal of Biochemical and Pharmacological Research. 2(4):185-190. PMCID: PMC4536951. 2014.

 

3.     Bai X, Hussong S. A new mouse model to study compensatory mechanisms that support normal motor function in Parkinson’s disease.Journal of Biochemical andPharmacological Research. 2(2):1-3. PMCID: PMC4578241. 2014.

 

4.     Bai X, Fermandez E,Gould G, Strong R. Homozygous deletion of glutathione peroxidase 1 and aldehyde dehydrogenase 1a1 genes is not associated with schizophrenia-like behavior in mice. Journal of Biochemical and Pharmacological Research. 1(4 ):228-2 35. PMCID: PMC3909525. 2013.

 

5.   EppolitoAK, Bai X, Gerak LR. Discriminative stimulus effects of pregnanolone in rats: role of training dose in determining mechanism of action. Psychopharmacology(Berl). 223(2):139-47. PMCID: PMC3490492. 2012.

 

6.  Bai X, France CP,Gerak LR. The discriminative stimulus effects of midazolam are resistant to modulation by morphine, amphetamine, dizocilpine, and γ-butyrolactone in rhesus monkeys. Psychopharmacology (Berl).217(4):495-504. PMCID: PMC3195358. 2011.

 

7. Bai X, Gerak LR.Comparing the discriminative stimuli produced by either the neuroactive  steroid pregnanolone or the benzodiazepine midazolam in rats. Psychopharmacology(Berl). 214(2):427-35. PMCID: PMC3030657. 2011.

 

8.    Liu X, Liu M, Zhang J, Bai X, Ramos F, VanRemmen H, RichardsonA, Liu F, Dong LQ, and Liu F. Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction. The American Journal of Physiology - Endocrinology and Metabolism. 296(5):E1067-75. PMCID: PMC2681306.2009.

 

 
     
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