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Dr. CRISTINA ESPINOSA DIEZ
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Address 1
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Address 2
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Title
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Dr.
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First Name
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CRISTINA
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Last Name
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ESPINOSA DIEZ
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University/Institution
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OHSU
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Email ID
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cristina.espinosa.diez@gmail.com
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City
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Portland
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Country
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United States
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State
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Oregon
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Zipcode
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97239
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Department
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Cell, Developmental and Cancer Biology
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Company Name
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Area of Research
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Tumor microenviroment
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Area of Expertise
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Angiogenes and microRNAs
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Brief Description of Research Interest :
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My main interest is to understand how microRNAs can modulate tumor angiogenesis altering DNA damage pathways. Our goal in the lab is combine the benefits of microRNA therapy with radiation or chemotherapy getting a better outcome and avoiding side effects or resistance to these treatments. Our second goal is to understand is how this microRNAs or their target depletion in the tumor endothelial cells can modify other tumor microenvironment responses.
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Representative Publications :
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Wilson R, Espinosa-Diez C, Kanner N, Chatterjee N, Ruhl R, Hipfinger C, Advani SJ, Li J, Khan OF, Franovic A, Weis SM, Kumar S, Coussens LM, Anderson DG, Chen CC, Cheresh DA, Anand S. MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment. Nat Commun. 2016 Nov 25;7:13597. doi: 10.1038/ncomms13597. PubMed PMID: 27886180.
Lu SC, Mato JM, Espinosa-Diez C, Lamas S. MicroRNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease. Free Radic Biol Med. 2016 Mar 24. pii: S0891-5849(16)00127-1. doi: 10.1016/j.freeradbiomed.2016.03.021. [Epub ahead of print] PubMed PMID: 27033954.
Espinosa-Diez C, Miguel V, Mennerich D, Kietzmann T, Sánchez-Pérez P, Cadenas S, Lamas S. Antioxidant responses and cellular adjustments to oxidative stress. Redox Biol. 2015 Dec;6:183-97. doi: 10.1016/j.redox.2015.07.008. Review. PubMed PMID: 26233704; PubMed Central PMCID: PMC4534574.
Espinosa-Diez C, Fierro-Fernández M, Sánchez-Gómez F, Rodríguez-Pascual F, Alique M, Ruiz-Ortega M, Beraza N, Martínez-Chantar ML, Fernández-Hernando C, Lamas S. Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-β-Dependent Fibrogenesis. Antioxid Redox Signal. 2015 Nov 10;23(14):1092-105. doi: 10.1089/ars.2014.6025. PubMed PMID: 25353619; PubMed Central PMCID: PMC4657521.
Fierro-Fernández M, Busnadiego Ó, Sandoval P, Espinosa-Díez C, Blanco-Ruiz E, Rodríguez M, Pian H, Ramos R, López-Cabrera M, García-Bermejo ML, Lamas S. miR-9-5p suppresses pro-fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX4 and TGFBR2. EMBO Rep. 2015 Oct;16(10):1358-77. doi: 10.15252/embr.201540750. PubMed PMID: 26315535; PubMed Central PMCID: PMC4766462.
ánchez-Gómez FJ, Espinosa-Díez C, Dubey M, Dikshit M, Lamas S. S-glutathionylation: relevance in diabetes and potential role as a biomarker. Biol Chem. 2013 Oct;394(10):1263-80. doi: 10.1515/hsz-2013-0150. Review. PubMed PMID: 24002664.
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