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Title : Dr.
First Name : MOHAMMAD I.
Last Name : ANSARI
University/Institution : University of Maryland School of Pharmacy
Phone # : 4432402108
Email ID : mansari@rx.umaryland.edu
City : Baltimore
Country : United States
State : Maryland
Zipcode : 21201
Department : Pharmaceutical Sciences
Company Name :
Area of Research
Development of Opioid Analgesics/Antidepresssants
Area of Expertise
Medicinal Chemistry
Brief Description of Research Interest :
My current research focuses on design and synthesis of molecules as potential tools to study biological systems concerned with drugs of abuse, smoking cessation, and depressants. Fundamental chemistry of drugs of abuse; novel transformations and improvement of known procedures. Structure-activity relationships; design of both selective ligands and mixed agonists/antagonists.
Representative Publications :
  1. A Novel Benzocoumarin-Stilbene Hybrid as a DNA ligase I inhibitor with in vitro and in vivo anti-tumor activity in breast cancer models; Mohd. Kamil Hussain, Deependra Kumar Singh, Akhilesh Singh, Mohd. Asad, Mohd. Imran Ansari, Mohammad Shameem, Shagun Krishna, Guru R. Valicherla, Vishal Makadia, Sanjeev Meena, Amit Laxmikant Deshmukh, Jiaur R. Gayen, Mohammad Imran Siddiqi, Dipak Datta, Kanchan Hajela, Dibyendu Banerjee;

Scientific Reports, 2017, DOI:10.1038/s41598-017-10864-3.

  1. Small molecule inhibitors of Ca2+-S100B reveal two protein conformations; M. C. Cavalier, Mohd. Imran Ansari, A. D. Pierce, P. T. Wilder, L. E. McKnight, E. P. Raman, S. L. Mercer, D. Neau, E. P. Bezwada, M. J. Alasadv, T. H. Charpentier, K. M. Varney, E. A. Toth, A. D. Mackerell, A. Coop, and D. J. Weber;

Journal of Medicinal Chemistry, 2016, 59, 592-608.

  1. Discovery of 3,4,6-triaryl-2-pyridones as potential anticancer agents that promote ROS-independent mitochondrial-mediated apoptosis in human breast carcinoma cells; Mohd. Imran Ansari, A. Arun, M. K. Hussain, R. Konwar and K. Hajela; Chemistryselect, 2016, 1, 4255-4264.
  2. Synthesis of targeted dibenzo[b,f]thiepines and dibenzo[b,f]oxepines as lead molecules with promising anti-breast cancer activity; Mohd. Imran Ansari, M. K. Hussain, A. Arun, B. Chakravarti, R. Konwar, and K. Hajela;

European Journal of Medicinal Chemistry, 2015, 99, 113-124.

  1.  Design and synthesis of ERα/ERβ selective coumarin and chromene derivatives as potential anti-breast cancer and anti-osteoporotic agents; M. K. Hussain, Mohd. Imran Ansari, N. Yadav, P. K. Gupta, A. K. Gupta, R. Saxena, I. Fatima, M. Manohar, P. Kushwaha, V. Khedgikar, J. Gautam, R. kant, P. R. Moulik, R. Trivedi, A. Dwivedi, K. R. Kumar, A. K. Saxena, K. Hajela;

RSC Advances, 2014, 4, 8828-8845.

  1. Tandem C-2 functionalization–intramolecular azide–alkyne 1,3-dipolar cycloaddition reaction: A convenient route to highly diversified 9H-benzo[b]pyrrolo[1,2-g][1,2,3] triazolo[1,5-d][1,4]diazepines; M. K. Hussain, Mohd. Imran Ansari, R. Kant and K. Hajela;

Organic Letters, 2014, 16, 560-563.

  1. Silica supported perchloric acid catalyzed rapid N-formylation under solvent-free conditions; Mohd. Imran Ansari, M. K. Hussain, N. Yadav, P. K. Gupta and K. Hajela; Tetrahedron Letters 2012, 53, 2063-2065. (Paper cited in Synfacts, 2012, 8 (6), 0680. Highlights in Current Synthetic Organic Chemistry).
  2. A highly efficient ultrasound-promoted synthesis of 2,3-disubstituted benzo[b]furans via intramolecular C–C bond formation in ionic liquid [bmim]BF4 at room temperature; N. Yadav, M.  K.  Hussain, Mohd.  Imran Ansari, P.  K. Gupta, and K.  Hajela;

RSC Advances, 2012, 3, 540-544.

  1. Eco-friendly HClO4-SiO2 catalyzed the synthesis of mono- and bis-diaryl-2H-1,4-benzothiazines; Mohd. Imran Ansari, R. Shankar, M. K. Hussain, R. Kant, P. R. Maulik, K. R. Kumar, and K. Hajela;

Journal of Heterocyclic Chemistry 2011, 1336-1341.

  1. Synthesis and biological evaluation of 3,4,6-triaryl-2-pyranones as a potential new class of anti-breast cancer agents; R. Shankar, B. Chakravarti, U. S. Singh, Mohd. Imran Ansari, S. Deshpande, S. K. D. Dwivedi, H. K. Bid, R. Konwar, G. Kharkwal, V. Chandra, A. Dwivedi and K.  Hajela;

Bioorganic & Medicinal Chemistry 2009, 17, 3847-3856.

  1. Abstarct Published 3,4,6-Triaryl-2-pyranone as a potential new class of anti-breast cancer agents; in a special issue of Medicinal Chemistry Research, 2010, 19, S70.


Book Chapter (Total No. 1)


  1. Multicomponent reactions for the generation of molecular libraries in anticancer drug discovery; M. Saquib, M. F. Khan, Mohd. Imran. Ansari, M. K. Hussain, J. Singh, 2016, Tayler & Francis Group, ISBN 9781498734127, }}{
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