A Journal of Postdoctoral Research.
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Title : Dr.
University/Institution : Harvard University
Phone # : 3016743108
Email ID : muthuirulanp@fas.harvard.edu
City : Cambridge
Country : United States
State : Massachusetts
Zipcode : 02140
Department : Human Evolutionary Biology
Company Name :
Area of Research
Development and Evolutionary Genetics
Area of Expertise
Microbiology, Genomics, Proteomics, Neuroscience and Genetics
Brief Description of Research Interest :
I am currently a Research Associate at the Department of Human Evolutionary Biology, Harvard University studying the developmental and genetic basis of human height variations and skeletal disorders using Functional Genomic Approaches.

Previously, I worked as a postdoctoral researcher at Section on Neuronal Connectivity, NICHD, National Institutes of Health. My research had focused on developing state of art tools using CRISPR-cas9 and high resolution imaging to map neurotransmitter receptors to neural circuits that involves visual motion processing in Drosophila.

During my Ph.D., at Department of Genetics, Madurai Kamaraj University, I took particular satisfaction from driving projects forward and answering emerging problem of antifungal drug resistance using metagenomics approaches. I had discovered a novel antifungal Peptide, MMGP1 from marine metagenome and characterized its distinct anti fungal mechanism against human opportunistic fungal pathogens, Candida albicans and Aspergillus.

With my research experiences, I have gained adequate knowledge in Omics technologies, functional genomics, antimicrobial drug discovery, protein engineering, mapping neural circuits, developmental and evolutionary genetics.

And also, exposure to a diverse mixture of academic and industrial research projects had developed me the ability to be highly productive working either as an individual or part of project teams. Exposure to various project teams during my graduation and postdoctoral research have allowed me to interact effectively with scientists across various disciplines. This collaborative experience has allowed me to communicate ideas effectively across numerous biological disciplines. These skill sets, in combination with my high levels of focus and attention to detail, scientific record keeping and time management skills allowed me to complete technically challenging scientific task with publishable quality of results.

Research Interest: Genomics, Proteomics, Microbiology, Neuroscience, Developmental and Evolutionary Genetics
Representative Publications :
  • Pushpanathan M (2018) Lab automation and robotics – accelerating the pace of antimicrobial therapy. Drug Target Review. Issue 1. pg: 6-8.
  • Muthuirulan, P. (2018). Do Microbes Care About Human Heart. J Infect Dis Immune Ther 2, 1, 2.
  • Velmurugan, G., Ramprasath, T., Swaminathan, K., Mithieux, G., Rajendhran, J., Dhivakar, M., ... Pushpanathan M (2017). Gut microbial degradation of organophosphate insecticides-induces glucose intolerance via gluconeogenesis. Genome biology, 18(1), 8.
  • Muthuirulan, P., & Gururajan, V. (2017). CRISPR Inspires New Hope to Disease Sufferers. Journal of Molecular Microbiology, 2(1).
  • Pushpanathan M (2017) Flow Cytometry: Accelerating Neuroscience Research. Drug Target Review, Issue #3
  • Muthuirulan, P., & Sharma, P. (2017). NGS: empowering infectious disease research beyond reality. Drug Target Review, 4(3), 45-50.
  • Pushpanathan, M. (2017) Lethal ovitrap: A cost-effective weapon to fight zika virus infection. vol.1 pg 1-2
  • Bandyopadhyay, M., & Muthuirulan, P. (2017). Androgen Signaling: Promising Target for Prospective Cancer Therapy. J Drug Des Devel, 1(1), 1-10.
  • Muthuirulan, P. (2017). CRISPR-Cas9: Promising platform for prospective antimicrobial therapy. Adv Tech Clin Microbiol, 1(1).
  • Pushpanathan M (2016) Versatile Applications of Next-Generation Sequencing in Pharmaceutics. Drug Target Review. Issue #4
  • Muthirulan, P., & Chandrasekaran, A. R. (2016). Microbial flow cytometry: an ideal tool for prospective antimicrobial drug development. Analytical biochemistry, 509, 89-91.
  • Pushpanathan M (2016) Flow Cytometry: Breaking Bottlenecks in Drug Discovery and Development. Drug Target Review. Issue #3
  • Pushpanathan M. (2016). Protect Your Microbiome to Stay Healthy and Disease-Free Life. EC Microbiology, 3, 482-484.
  • Muthuirulan, P. (2016). Integrating Omics Technologies for Prospective Antimicrobial Drug DevelopmentJ Cell Biol Mol Sci 1 (1): 1-7. J Cell Biol Mol Sci, 1(1).
  • Pushpanathan, M. (2016). Era of Antimicrobials: Winning Microbes. J Bacteriol Mycol Open Access, 2(2), 00021.
  • Muthuirulan, P. (2016). Insight into Phenotypic and Genotypic Discrimination of Bacterial Pathogens: From Pre-Genomic to Post-Genomic Era. BAOJ Med Nursing, 2, 018.
  • Pushpanathan M (2016 ) Leaky Gut Syndrome: Mystery Illness Triggered by Candida albicans. Journal of Nutritional Health & Food Engineering. 4:
  • Manjula, A*., Pushpanathan, M*., Sathyavathi, S., Gunasekaran, P., & Rajendhran, J. (2016). Comparative analysis of microbial diversity in termite gut and termite nest using ion sequencing. Current microbiology, 72(3), 267-275 (*equal contribution).
  • Pushpanathan, M., Pooja, S., Gunasekaran, P., & Rajendhran, J. (2016). Critical evaluation and compilation of physicochemical determinants and membrane interactions of MMGP1 antifungal peptide. Molecular pharmaceutics, 13(5), 1656-1667.
  • Chandrasekaran, A. R., Pushpanathan, M., & Halvorsen, K. (2016). Evolution of DNA origami scaffolds. Materials Letters, 170, 221-224.
  • Pushpanathan, M. (2016). Chasing new drugs against infectious diseases: a herculean task. J Clin Case Rep, 6(859), 2.
  • Ranjani, J., Pushpanathan, M., Mahesh, A., Niraimathi, M., Gunasekaran, P., & Rajendhran, J. (2015). Pseudomonas aeruginosa PAO1 induces distinct cell death mechanisms in H9C2 cells and its differentiated form. Journal of basic microbiology, 55(10), 1191-1202.
  • Pooja, S., Pushpanathan, M., Gunasekaran, P., & Rajendhran, J. (2015). Endocytosis‒Mediated Invasion and Pathogenicity of Streptococcus agalactiae in Rat Cardiomyocyte (H9C2). PloS one, 10(10), e0139733.
  • Pooja, S., Pushpanathan, M., Jayashree, S., Gunasekaran, P., & Rajendhran, J. (2015). Identification of periplasmic α-amlyase from cow dung metagenome by product induced gene expression profiling (pigex). Indian journal of microbiology, 55(1), 57-65.
  • Jayashree, S., Pooja, S., Pushpanathan, M., Rajendhran, J., & Gunasekaran, P. (2014). Identification and characterization of bile salt hydrolase genes from the genome of Lactobacillus fermentum MTCC 8711. Applied biochemistry and biotechnology, 174(2), 855-866.
  • Dinakaran, V., Rathinavel, A., Pushpanathan, M., Sivakumar, R., Gunasekaran, P., & Rajendhran, J. (2014). Elevated levels of circulating DNA in cardiovascular disease patients: metagenomic profiling of microbiome in the circulation. PLoS One, 9(8), e105221.
  • Manjula, A., Sathyavathi, S., Pushpanathan, M., Gunasekaran, P., & Rajendhran, J. (2014). Microbial diversity in termite nest. Current Science, 1430-1434.
  • Pushpanathan, M., Jayashree, S., Gunasekaran, P., & Rajendhran, J. (2014). Microbial Bioremediation: A Metagenomic Approach. In Microbial Biodegradation and Bioremediation (pp. 407-419).
  • Pushpanathan, M., Rajendhran, J., & Gunasekaran, P. (2013). Proteolytic Activity of the MMGP1 Antifungal Peptide Derived from Marine Metagenome. International Journal of Peptide Research and Therapeutics, 19(4), 331-336.
  • Jayashree, S., Pooja, S., Pushpanathan, M., Vishnu, U., Sankarasubramanian, J., Rajendhran, J., & Gunasekaran, P. (2013). Genome sequence of Lactobacillus fermentum strain MTCC 8711, a probiotic bacterium isolated from yogurt. Genome announcements, 1(5), e00770-13.
  • Jayashree, S., Pushpanathan, M., Rajendhran, J., & Gunasekaran, P. (2013). Microbial diversity and phylogeny analysis of buttermilk, a fermented milk product, employing 16S rRNA-based pyrosequencing. Food biotechnology, 27(3), 213-221.
  • Pushpanathan, M., Gunasekaran, P., & Rajendhran, J. (2013). Mechanisms of the antifungal action of marine metagenome-derived peptide, MMGP1, against Candida albicans. PloS one, 8(7), e69316.
  • Pushpanathan, Muthuirulan, Paramasamy Gunasekaran, and Jeyaprakash Rajendhran. "Antimicrobial peptides: versatile biological properties." International journal of peptides 2013 (2013).
  • Sundarakrishnan, B., Pushpanathan, M., Jayashree, S., Rajendhran, J., Sakthivel, N., Jayachandran, S., & Gunasekaran, P. (2012). Assessment of microbial richness in pelagic sediment of Andaman sea by bacterial tag encoded FLX titanium amplicon pyrosequencing (bTEFAP). Indian journal of microbiology, 52(4), 544-550.
  • Pushpanathan, M., Rajendhran, J., Jayashree, S., Sundarakrishnan, B., Jayachandran, S., & Gunasekaran, P. (2012). Identification of a novel antifungal peptide with chitin-binding property from marine metagenome. Protein and peptide letters, 19(12), 1289-1296.
  • Pushpanathan, M., Rajendhran, J., Jayashree, S., Sundarakrishnan, B., Jayachandran, S., & Gunasekaran, P. (2012). Direct cell penetration of the antifungal peptide, MMGP1, in Candida albicans. Journal of Peptide Science, 18(11), 657-660.
  • Pushpanathan, M., & Pandian, R. S. (2008). Culture filtrate of Pseudomonas fluorescens Migula an ideal ovitrap agent for the vectors of dengue and chikungunya, Aedes aegypti (Linn.) and Aedes albopictus (Skuse). Current Biotica, 2(4), 461-471.
  • Pushpanathan, M., & Pandian, R. S. (2008). Management of dengue and chikungunya vectors Aedes aegypti (Linn) and Aedes albopictus (Skuse)(Diptera: Culicidae) by the exotoxin of Pseudomonas fluorescens Migula (Pseudomonadales: Pseudomonadaceae). Current Biotica, 2(1), 74-103.

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