A Journal of Postdoctoral Research.
     Login   |   Register   
    ISSN : 2328-9791
left right
Sphingolipid targeting in inflammation and fungal infection
Caretti A, Perdoni F, Falleni M, Tosi D, Casas J, Fabrias G, Ghidoni R, Borghi E, Signorelli P
University of Milan
University of Milan, Dept. Health Sciences, Biochemistry & Mol. Biology Lab.; University of Milan, Dept. Health Sciences, Microbiology Lab...

Background. The sphingolipid mediator ceramide accumulates in chronic inflammatory diseases, such as Cystic Fibrosis and COPD, promoting inflammation and favoring infection. Sphingolipids (SPLs) are essential components of fungal membranes and signaling. Myriocin (Myr) inhibits SPLs synthesis in both human and fungi. We previously demonstrated that Myr loaded nanocarriers (SLN) reduces CF mice lung inflammation, ceramide content and P. aeruginosa infection (Caretti et al BBA 2014).

Hypothesis. We hypothesize that Myr modulation of SPLs synthesis, by lowering ceramide expression level, could reduce A. fumigatus infection and inflammation in both in vitro and in vivo CF models.


home phone mail info@postdocjournal.com
twitter facebook social icon Social link You Tube sky
Click Here