A Journal of Postdoctoral Research.
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The Role of TET Proteins During Development
Rita Khoueiry, and Kian Peng Koh.
Stem Cell Institute Leuven
KU Leuven Department of Development and Regeneration, Stem Cell Institute Leuven, 3000 Leuven, Belgium. 

In 2009, a new family of DNA modifying enzymes, the Tet-eleven translocation family was identified as 2-oxoglutarate (2-OG) and Fe(II)-dependent dioxygenases. This family of enzymes comprises three proteins TET1, TET2 and TET3 that share a carboxyl-terminal core catalytic domain consisting of a conserved cysteine-rich domain, a double stranded β-helix domain and binding sites for the cofactors Fe(II) and 2-oxoglutarate. At their amino-terminal region, TET1 and TET3 have a CXXC DNA-binding domain. Interestingly, during evolution, the segment encoding the CXXC domain of TET2 was separated from the region encoding the catalytic domain and is now encoded separately by a neighboring gene, IDAX (also called CXXC4).


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