A Journal of Postdoctoral Research.
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Genes and signaling pathways affecting the pathogenesis of melanoma
Bridget E. Varughese and Rohinton Sarosh Tarapore
University of Pennsylvania Perelman School of Medicine
Department of Biological Sciences, Wayne State University, Detroit, MI :
University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Melanoma is probably the most aggressive cancer in humans and remains one of the leading causes of cancer deaths in developed countries. Melanoma represents a very small proportion of skin cancer incidences but is responsible for >80% skin cancer deaths. Ultraviolet radiation emitted from the sun is the main contributing factor towards the development of melanomas. Novel strategies against melanoma are required and more research needs to be carried out towards the development of new chemotherapeutic and biological agents that can target the disease. In this review, the genes and signaling mechanisms that play an essential role in the development and progression of melanoma are described.

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