A Journal of Postdoctoral Research.
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Oxidative Stress and Inflammation : 'THE LESSER OF TWO EVILS' In Carcinogenesis
Naveen Kaushal and Avinash K. Kudva
The Pennsylvania State University
Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Literature is replete with reports indicating the involvement of oxidative stress and inflammation in tumorigenesis. Reactive oxygen species (ROS) are by-products of various oxidized cellular metabolites that serve as the “business end” as well as the consequence of oxidative stress leading to DNA damage, mutagenesis, and destruction of diverse biological macromolecules. These events may eventually culminate in carcinogenesis- through varied mechanisms such as inhibition of apoptosis, increased cellular proliferation, angiogenesis, and disruption of DNA repair mechanism. Inflammation per se.....

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