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Adapt or Dye: Tumor Microenvironment, A Powerful Regulator of Cancer Progression
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María Apellániz-Ruiz and Zafira Castaño
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1Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Center, Madrid, Spain, 2Hematology Division, Brigham & Women’s Hospital, Boston, Massachusetts
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1Spanish National Cancer, Research Center, Madrid, Spain
2Hematology Division, Brigham & Women’s Hospital, Boston, Massachusetts, USA
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zcastano-corsino@partners.org
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Tumorigenesis is a complex multistep process in which a plethora of tumor and stromal cells play important roles. From this point of view, the biology of a tumor can be elucidated by focusing on the crosstalk between tumor cells and the tumor microenvironment, comprised by stromal cells of different origins. Several lines of evidence demonstrate essential contributions of tumor stromal cells, which influence the growth, survival, invasiveness, and metastatic ability of neoplastic epithelial cells within these tumors. This review describes the role of the microenvironment during tumor progression, and suggests possible new therapeutic avenues.
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