A Journal of Postdoctoral Research.
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Reduced glucose metabolism in CD4 T cells linked to rheumatoid arthritis
Ann L. Jagger
Stanford University
Department of Cardiovascular Medicine, Stanford University, Stanford, CA, United States
Rheumatoid arthritis (RA) is an inflammatory disease of the joints that, if untreated, leads to cartilage destruction, bone erosion and ultimately loss of joint mobility (Scott, 2010). Inflammation is both the principal clinical manifestation of the disease, as well as the driver of synovial tissue damage. As the incidence of RA strongly correlates with advancing age, it is believed that age-related dysregulation of the immune system may play an important role in its pathogenesis and chronicity (Lindstrom, 2010). This age-related decline of the immune system, known as immune senescence, appears to follow an accelerated trajectory in patients with RA.

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