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Discoidin Domain Receptor 2 (DDR2): an emerging player in breast cancer metastasis
Rajeshwari R. Valiathan
Wayne State University
Department of Pathology, Wayne State University School of Medicine, Detroit, MI, United States.
Epithelial to Mesenchymal Transition (EMT) is a key driver of breast cancer progression and metastasis. Several transcription factors, including SNAIL1, SLUG, TWIST1 and Zeb have been implicated in the induction of EMT. In the case of SNAIL1, a differential expression pattern of mRNA and protein has been observed in primary tumors from patients, with mRNA expression generally present throughout the tumor and protein expression found predominantly at the tumor-stroma interface. How SNAIL1 protein expression and hence EMT is maintained only at the tumor front is not very well understood. To address this question, Zhang et al previously conducted a short interfering RNA (siRNA) screen to identify regulators of total cellular SNAIL1 protein levels. They identified Discoidin Domain Receptor 2 (DDR2), a novel receptor tyrosine kinase (RTK) that signals...

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