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Discovery and development of dabigatran.
Preetpal S Sidhu.<br />
Department of Chemistry and Biochemistry, UW, Milwaukee, WI 53211, USA.<br />
Preetpal S Sidhu.
University of Wisconsin, Milwaukee.
Department of Chemistry and Biochemistry, UW, Milwaukee, WI 53211, USA.
sidhup@uwm.edu
Thrombin is key protease involved in regulation of coagulation cascade and thus, highly targeted to design the newer anticoagulant. Various direct and allosteric inhibitors of thrombin were designed but few made their way to clinic. Dabigatran is direct inhibitors of thrombin approved by FDA for clinical use. This article highlights the discovery and development of dabigatran as newer anticoagulant drug.
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