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Discovery of Selective Vitamin D Receptor Coregulator Inhibitor
Preetpal S Sidhu<br />
Department of Chemistry and Biochemistry, UW Milwaukee, WI 53211, USA
Preetpal S Sidhu
University of Wisconsin-Milwaukee
Department of Chemistry and Biochemistry, UW Milwaukee, WI 53211, USA
preetpalsidhu@gmail.com
Vitamin D Receptor (VDR) is known to be involved in calcium homeostasis and recently, for its role in cell growth and differentiation. Here, we present the research highlight for discovery of selective inhibitor which blocks the interactions between VDR and co-regulators. This review discusses the anti-cancer effect of lead inhibitors in cancer cell-lines and its role in regulation of various VDR related genes.
Madireddy Lab
Genetics Society of America
American Society for Biochemistry and Molecular Biology
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