Myelin associated proteins are known to pose hurdles to central nervous system (CNS) axon regeneration. The myelin mediated inhibition on axon regeneration can be reversed by brain derived neurotrophic factor (BDNF). BDNF enhances cyclic AMP (cAMP) levels for eliciting its beneficial effects on axon regeneration. A recent article by Martinez et al., revealed that soluble adenylyl cyclase (sAC) is a potential catalytic source for cAMP in BDNF stimulated neurons. Interestingly BDNF stimulated or exogenously administered sAC was able to reverse the inhibitory effects of myelin on axon regeneration suggesting that sAC is a potential therapeutic opportunity in CNS injury.