Protein phosphorylation ensures the accurate sequence of events underlying multiple signaling pathways, such as cell survival and cell proliferation. Using a combination of cell biology and molecular techniques, Vera et al. [20] have discovered an active role of Greatwall kinase in cell proliferation, transformation and invasiveness of human cancers through the Akt pathway, one of the most acknowledged oncogenic signaling networks in cells. This paper opens new horizons for human therapies in which Greatwall kinase can be used as a potential oncogenic marker and/or as a potential therapeutic target in aggressive human cancers.