Dragmacidin D, a bis(indole) alkaloid was isolated from deep water marine sponge in 1992 and 1998. The structural feature consists of two unsymmetrically substituted indole moiety connected through a pyrazinone linker and has a polar aminoimidazole moiety. Due to remarkable structural features and diverse biological properties, dragmacidin D has attracted attention from synthetic community. In this review, the syntheses of dragmacidin D for last 13 years are briefly summarized.